KIZOO provides mentoring, seed and early-stage financing with a focus on rejuvenation biotech.
Having been entrepreneurs, VCs and mentors in both, high growth tech and biotech companies ourselves for many years with multiple exits and massive value created for the company founders, we now bring this experience to the emerging field of rejuvenation biotech - a young industry that will eventually become much bigger than today's largest technology markets.
If you are looking for financing and support please feel free to send your story to [email protected]
Having been entrepreneurs, VCs and mentors in both, high growth tech and biotech companies ourselves for many years with multiple exits and massive value created for the company founders, we now bring this experience to the emerging field of rejuvenation biotech - a young industry that will eventually become much bigger than today's largest technology markets.
If you are looking for financing and support please feel free to send your story to [email protected]
Accelerating Rejuvenation Biotech
As part of the Forever Healthy Group, we directly support the creation of startups that turn research on the root causes of aging into therapies and services for humans.
Forever Healthy's other initiatives include the evaluation of new rejuvenation therapies, evidenced-based curation of the world's cutting-edge medical knowledge, funding research projects on the root causes of aging and hosting the annual Undoing Aging Conference.
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Revel opens up an entirely new field in the treatment of age-related molecular damage - breaking crosslinked collagen fibers.
Collagen is an essential part of the structural framework of the body. Unfortunately, it sometimes binds with glucose to form stiff, sofar unbreakable bonds that accumulate over time. Crosslinks cause hardening of tissues such as muscle, skin, and arteries leading to increased blood pressure, vascular damage, and wrinkling of the skin. Based on 10 years of research by Yale Professors David Spiegel and Jason Crawford Revel will produce crosslink-breaking drugs. |
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Underdog develops simple and direct interventions targeting toxic forms of cholesterol, using rationally designed molecules, to provide the first true disease-modifying treatments for age-related diseases such as atherosclerosis, hypercholesterolemia, heart failure, and macular degeneration.
Its products are based on novel derivatives of a well-known, safe compound, and a new way of looking at cardiovascular disease created through a SENS Research Foundation program. |
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MAIA Biotechnology is dedicated to developing targeted cancer therapies with novel mechanisms of action that are intended to meaningfully improve and extend the lives of patients with cancer.
Telomerase is present in 90% of human cancer cells and contributes significantly to proliferative abilities and immortality of cancer cells. It is either absent or shows low activity in normal cells. THIO(6-thio-dG) is recognized by telomerase and incorporated into telomeres. Once incorporated, it compromises telomere structure and function, leading to ‘uncapping’ of the chromosome ends resulting in rapid tumor cell death. |
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LIfT Biosciences is developing the world's first cell therapy to destroy all solid tumours, irrespective of strain or mutation by building the World's 1st cell bank of innately cancer killing neutrophils (a type of white blood cell).
The cell bank will enable LIfT to provide a range of potentially life-saving immuno-oncology cell therapies for different solid tumour types. The first step is to show remission in high unmet need solid tumours by 2021, including Pancreatic Cancer. |
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Turn Biotechnologies is a Stanford spinout developing therapies to effectively return mature differentiated cells to a dramatically younger state leaving their differentiated identity unaltered.
Turn Biotechnologies surpasses traditional approaches based on single gene/pathway manipulations and tackles the multifaceted manifestation of cellular age at the organ, tissue, and organismal level to extend the healthspan of people. As a result, age is reset by epigenetically reprogramming cells. |
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Elevian is a Harvard spinout developing therapeutics to stimulate regenerative capacity, the body’s ability to repair itself, that declines as we age.
Elevian’s founders have identified circulating blood factors, including GDF11, that broadly stimulate regenerative capacity in aged animals in many organs and tissues (e.g. brain, heart, pancreas, muscle, and others). Initially planned indications include Alzheimer’s disease, heart failure, Type II diabetes, and age-related muscle dysfunction. |
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Antoxerene uses proprietary next generation screening technology to identify small-molecule compounds that target pathways of aging.
The team focuses on next generation screens with higher predictive value than traditional approaches and expects first on-target therapeutic candidates for the p53/MDM2 pathway, a oncology target, and the p53/FOXO4 pathway, a newly identified pathway involved in cellular aging. |
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FoxBio will develop Antoxerene’s collection of small molecules that specifically target senescent cells.
There has been a lot of interest surrounding the therapeutic applications of senolytic drugs – compounds that clear toxic senescent cells – particularly with respect to age-associated disease. As molecular pathways unique to senescent cells have begun to be identified, drugs to target these pathways can now be developed. |
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AgeX Therapeutics is applying technology relating to cell immortality and regenerative biology to aging and age-related diseases.
The company has three initial areas of product development: pluripotent stem cell-derived brown adipocytes; vascular progenitors; and induced tissue regeneration. Initially planned indications for these products are Type II diabetes, cardiac ischemia, and cancer respectively. |
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Oisin is developing a cellular repair therapy based on a genetically-targeted intervention to clear senescent cells from our body.
When a cell reaches the end of its life or becomes damaged beyond repair it is supposed to either kill itself or signal the immune system to remove it. Unfortunately every so often this mechanism fails, the cell stays around indefinitely and starts poisoning it's environment. Over time we accumulate more and more of these harmful, death resistant senescent cells. A recent study in rodents has shown that clearing senescent cells can both reduce the negative effects of age-related diseases and extend the healthy lifespan by up to 35%. |
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Lysoclear is developing a novel molecular repair therapy to treat Age-related Macular Degeneration (AMD) and restore vision.
AMD is the leading cause of vision loss among people over the age of 50. It is thought to be caused by aggregation of A2E a toxic, non-degradable cellular waste product in our eye's retina cells. Lysoclear´s molecular repair approach is based on the targeted delivery of exogenous A2E degrading enzymes to our retinal cells to eliminate A2E. The team recently announced a Series-A offering to bring its product through Phase I clinical trials. LysoClear would be the first clinical candidate based on the repair and rejuvenation paradigm, pioneered by the SENS research foundation. |
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CellAge is aiming to increase human healthspan and reduce the incidence of age-related diseases by helping the human body destroy senescent cells. The team is focusing on a novel approach for this challenge by developing synthetic promoters for senescence cell detection and removal.
The teams joint expertise in senescence, synthetic biology and bioinformatics gives CellAge a unique angle on improving ways that gene therapies could be targeted to senescent cells. |
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Grapeseed.Bio is a life science accelerator program for young companies that develop therapeutic interventions for age-associated diseases.
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Our annual Undoing Aging Conference is focused on the cellular and molecular repair of age-related damage as the basis of therapies to bring aging under full medical control.
Among the 40 brilliant speakers at Undoing Aging 2019, there were giants in regenerative medicine such as: Dr. Nir Barzilai, Dr. Jerry Shay, Dr. Evan Snyder, Dr. Judith Campisi, and many more. Undoing Aging 2020 will once again bring together scientists and startups from around the globe, all pioneers in their respective fields, who are leading the charge in maintaining and restoring full health in old age.
Among the 40 brilliant speakers at Undoing Aging 2019, there were giants in regenerative medicine such as: Dr. Nir Barzilai, Dr. Jerry Shay, Dr. Evan Snyder, Dr. Judith Campisi, and many more. Undoing Aging 2020 will once again bring together scientists and startups from around the globe, all pioneers in their respective fields, who are leading the charge in maintaining and restoring full health in old age.
Technology Ventures
Being part of the German Internet right from the beginning, founding, funding and developing several major internet companies ourselves, has been an incredible journey for us. We are still excited to support and mentor some of our country's most promising startups.
Staffbase closes the intranet gap for non-desk workers. It is a ready-to-go SaaS solution to extend the reach of internal communications to employees working outside the office, a group representing more than 2/3 of the global workforce. |
Mambu enables any financial institution to easily deliver state-of-the-art banking through its software-as-a-service cloud solution. Agile, flexible and open, Mambu eliminates the complexities typically associated with core banking software, at a fraction of the cost.
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Babbel has made learning languages fun, easy and accessible to everyone. The market-leading app consists of high-quality courses in 14 learning languages (Spanish, French, English, German, Italian, Brazilian Portuguese, Turkish, Polish, Indonesian, Dutch, Norwegian, Danish, Swedish and Russian). |
MOQO is the SaaS-engine for shared mobility services. Its cloud-based platform enables everyone to offer shared mobility services with outstanding quality and exceptional economy of scale.
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Shyftplan is an online shift-planning service that SMEs can use to organize and communicate with their employees. Company administrators can quickly and easily create the payroll for all employees. |
Prescreen is an e-recruiting solution that enables organizations to optimize their recruiting process. The system helps HR departments in the advertising of job vacancies, the search and recruitment process, as well as interviewing and assessment of candidates.
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Suitepad is a new communication channel that brings hotels and their guests closer together, renders an even more comfortable guests experience, and yields additional financial value for hotels.
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Tamyca is Germany's first and leading peer-to-peer carsharing marketplace, connecting car owners whose vehicles are sitting idle for most hours of the day with people who need a car.
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REVL is a new kind of action camera, a better camera. One that allows you to enjoy the moment, knowing your footage will look great and you can spend less time editing and more time having fun.
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MegaZebra is a developer and publisher of Social Games. Its platform allows users of social networks to play online games against their friends. Millions of games are being played by its users. |
Management
Michael Greve
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Michael and his brother Matthias are among the most successful founders of the German-speaking Internet industry.
Alongside numerous other ventures, they created lastminute.de and turned it into the largest last-minute travel site in Germany. Most notably, the brothers founded WEB.DE , and after a successful IPO, grew it into one of the country's largest internet portals and online media businesses. After the successful sale of his companies, Michael created the seed-stage venture capital investor Kizoo that came to fund and mentor some of Germany's most promising tech startups including Babbel, Mambu, and Staffbase. Forever Healthy started out more than a decade ago as a personal quest to shed the extremely unhealthy lifestyle he acquired while building WEB.DE, and over time turned into the focus of his entrepreneurial energy: To enable people to vastly extend their healthy lifespan and be part of the first generation to cure aging. Initiatives of Forever Healthy include the evaluation of new rejuvenation therapies, evidenced-based curation of the world's cutting-edge medical knowledge, the annual Undoing Aging Conference, funding research projects on the root causes of aging, and supporting the creation of startups turning that research into therapies for human use. |
Matthias Hornberger
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Matthias is CFO of Kizoo. He has been part of the senior management team of the group since the IPO of the AG in 2000.
With his long-standing experience in the investment sector and his comprehensive knowledge of typical features of successful business models, he is a competent reference person for young founders. Matthias has extensive contacts in the high-tech industry and numerous local and national networks. Before joining the AG he had a career in Investment Banking. He studied Business Administration at Universities in Mannheim and Toronto (Dipl.-Kfm). |
Frank Schüler
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Frank Schueler, MSc is Managing Director of Kizoo.
Frank led the IPO of web.de, co-founded the Kizoo Venture Capital business with Michael and Matthias, and since then has helped numerous startups to grow. Among Franks board-level assignments, he is COO of the Forever Healthy Foundation, co-founder of the Undoing Aging science conference series, member of the board of the SENS Research Foundation, Mountain View, California and on the executive board of Atevia AG, a public company for 16 years. Previously, he was a strategy consultant with PriceWaterhouseCoopers. Frank holds a M.Sc. (New York) and a Dipl.-Wirtsch.-Ing. from Karlsruhe Institute of Technology (KIT), Germany. |
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Patrick Burgermeister
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Patrick Burgermeister recently joined Kizoo coming from the venture capital group BioMedPartners where he was one of the partners. His experience in the industry encompasses both banking (as a senior analyst for pharma/biotech) as well as pharma (as a senior portfolio manager at Novartis). Patrick supported various biotech companies as a director on their boards, was a successful business developer for early-stage biotech companies and led collaboration and licensing deals with public and private companies. He headed business development at several companies including Apeiron Biologics and BioVersys.
Patrick holds a Master's degree in molecular biology from the University of Basel, an MBA from the University St. Gallen and a degree as a Chartered Financial Analyst (CFA). |